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Endocrine Abstracts

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ea0086p328 | Metabolism, Obesity and Diabetes | SFEBES2022

Vernonia amygdalina Alleviates Neurodegenerative Effects of High Fat Diet and Streptozotocin-Induced Type 2 Diabetes Mellitus in the Hippocampi of Adult Male Wistar Rats

Afees Olanrewaju John , Olufunmilola Ekundayo Ifeoluwa , Oluwaseyi Adeniji Kehinde , Igbo Enya Joseph , Arietarhire Leviticus , Soremekun Oladimeji , Ogunbiyi Olubunmi , Bamidele Richard , Taiye Adelodun Stephen , Yinka Olatunji Sunday , Afolabi Toluwanimi , Zabdiel Abijo Ayodeji , Owolabi Joshua

Cognitive impairment and neurodegeneration are a few hallmarks of brain insulin resistance, a core feature of Type 2 diabetes mellitus (T2DM). Using a Wistar rat model of a high-fat diet and streptozotocin-induced T2DM, we aimed to determine the potential of Vernonia amygdalina (VA) as a possible treatment for the accompanied neurodegenerative effects of this condition on hippocampal structure and function. T2DM adult rats were prepared by a combination of a high-fat diet and ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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